| Pair Name | Anacardic Acid, Bortezomib | ||
| Phytochemical Name | Anacardic Acid (PubChem CID: 167551 ) | ||
| Anticancer drug Name | Bortezomib (PubChem CID: 387447 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Anacardic Acid, Bortezomib | |||
| Disease Info | [ICD-11: 2A83] | Multiple myeloma | Investigative | |
| Biological Phenomena | Induction-->Endoplasmic reticulum stress | |||
| Gene Regulation | Up-regulation | Expression | ATF4 | hsa468 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP8 | hsa841 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Up-regulation | Expression | DDIT3 | hsa1649 | |
| Up-regulation | Phosphorylation | EIF2S1 | hsa1965 | |
| Up-regulation | Expression | HSPA4 | hsa3308 | |
| Up-regulation | Expression | HSPA5 | hsa3309 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | U266B1 | Plasma cell myeloma | Homo sapiens (Human) | CVCL_0566 |
| Result | The results of the present study suggest that AA/Bor combination may be a potential therapeutic strategy for MM treatment. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combined therapeutic effects of bortezomib and anacardic acid on multiple myeloma cells via activation of the endoplasmic reticulum stress response. Mol Med Rep. 2016 Sep;14(3):2679-84. doi: 10.3892/mmr.2016.5533. | Click |
